It is the last version of Microsoft Office to support Windows XP SP3 32-bit, Windows Server 2003 SP2 32-bit, Windows Vista SP1 or later, and Windows Server 2008 as the following version, Microsoft Office 2013 only supports Windows 7 and Windows Server 2008 R2 or later. Office 2010 is compatible with Windows XP SP3 32-bit, Windows Server 2003 SP2 32-bit through Windows 10 and Windows Server 2016. It is also the first version to require volume license product activation.

Office 2010 is the first version of Office to ship in a 64-bit version. Office Mobile 2010, an update to Microsoft's mobile productivity suite was released on as a free upgrade from the Windows Phone Store for Windows Mobile 6.5 devices with a previous version of Office Mobile installed. A new Office Starter 2010 edition replaces Microsoft Works. It debuted Office Online, free Web-based versions of Excel, OneNote, PowerPoint, and Word. Collaborative editing features that enable multiple users to share and edit documents extended file format support integration with OneDrive and SharePoint and security improvements such as Protected View, a sandbox to protect users from malicious content are among its other new features. The ribbon introduced in Office 2007 for Access, Excel, Outlook, PowerPoint, and Word is the primary user interface for all applications in Office 2010 and is now customizable. Office 2010 introduces user interface enhancements including a Backstage view that consolidates document management tasks into a single location.

The macOS equivalent, Microsoft Office 2011 for Mac was released on October 26, 2010. Microsoft Office 2010 (codenamed Office 14 ) is a version of Microsoft Office for Microsoft Windows unveiled by Microsoft on May 15, 2009, and released to manufacturing on April 15, 2010, with general availability on June 15, 2010, as the successor to Office 2007 and the predecessor to Office 2013. English, Arabic, Bulgarian, Chinese (Simplified), Chinese, Croatian, Czech, Danish, Dutch, Estonian, Filipino, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Italian, Japanese, Kazakh, Korean, Latvian, Lithuanian, Norwegian (Bokmål), Polish, Portuguese (Brazil), Portuguese (Portugal), Romanian, Russian, Serbian, Slovak, Slovenian, Spanish, Swedish, Thai, Turkish, Ukrainian

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